SPDP(SPDP Crosslinker)

 SPDP的化学信息：

Cat. No.:  HY-100216
CAS No.:68181-17-9
Molecular Formula:C12H12N2O4S2  
Molecular Weight:312.36
Target:Others
Pathway:Others
Solubility:Water-insoluble (dissolve in DMF or DMSO)
  SPDP的分子结构式

SPDP的生物活性

        SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .
  相关文献  

[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7.

[2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.

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